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Dr Südhof: 'We understand maybe one or two per cent of what happens in the brain'

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20141119PHT79615_original"The brain is incredibly difficult to understand. We know maybe one or two per cent," said Dr Thomas Südhof, speaking before a lecture about the brain at the European Parliament on 18 November. The 2013 Nobel Prize for Medicine laureate was invited by the European Parliament’s Science and Technology Options Assessment (STOA) body for its annual lecture.


What got you interested in brains?
When I started my lab 30 years ago, I was looking for a new project in the area of science that would allow me to do something completely different. I decided to work on the brain because it is incredibly difficult to understand. We know maybe one or two per cent.

How could research into the brain's chemistry lead to tackling diseases such as Alzheimer's, schizophrenia and autism? What promising developments are there at the moment?

A lot of money has been wasted on clinical trials that have failed, because we don’t understand diseases like Alzheimer's or autism. If you don’t understand it, you don’t know how to treat it. And then every attempt at remedial treatment is basically a guess and these are very expensive guesses.

Have you seen changes in how research is funded?

I have seen dramatic changes and I believe many of these changes are wrong. Many funds will be misdirected and wasted if the science funding is not dedicated to scientists based on merit and realistic assessments of what can be done. Many scientists overpromise in order to get more money and we need ways of containing this as it will inevitably lead to disappointment

What role should the European Union play in stimulating research?

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There is a tremendous role for the European Union to play because the European Union has become one of the most important funders of European research. It has a crucial role as its funding will have a major role in determining what type of science is advancing.

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