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Last chance to register for EAPM EU Presidency Conference

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Hello, health colleagues, and welcome to the European Alliance for Personalised Medicine (EAPM) update – we are looking forward very much to the 9th EU Presidency Conference, under the auspices of the Portuguese EU Presidency, which takes place online on Monday, 8 March from 9-16h CET – the aim of the game is all about establishing a health policy framework across the EU, writes EAPM Executive Director Denis Horgan.

EU Presidency Conference
The EAPM conference will feature a wide range of keynote speakers from across the EU, including Christine Chomienne, vice chairwoman of the Mission Board Cancer at the European Commission and professor of Cellular Biology at the Université deParis, France, MEP Pernille Weiss, and Daria Julkowska, co-ordinator of the European Joint Programme on Rare Diseases.

In terms of the themes undertaken by the conference, these will include propelling health care through an effective governance framework, and update on the Europe Beating Cancer Plan, and the role of biomarkers and advanced molecular diagnostics.

Health-care systems are not always ready to respond to the opportunities. The disruptive nature of personalised care challenges traditional patterns of thinking. Practices, presumptions and even prejudices that date from before the millennium resist a 21st century approach to healthcare.

The conference will be seeking to move towards establishing a policy framework, in order to realize the potential of personalised health care, and not only in Europe: Europe’s engagement in global research and scientific enterprise can benefit the population of the entire planet.

As far as the conference is concerned, it is absolutely clear that it is necessary to formulate a personalised healthcare-centred strategy involving decision makers and regulators in the arena of public health, to enable the EU and member states to contribute to integrating personalised medicine into clinical practicewhile enabling much-greater access for patients.

For the opening session, which is entitled propelling health care through an effective governance framework, at the start of the 2020s, wide-ranging changes are under way in European society and governance, with a new European Commission, a freshly-elected European Parliament, and a growing conviction among Europe’s policymakers that people must be at the centre of any successful and sustainable strategy. The ambition of new Commission President Ursula von der Leyen is a Europe that ‘must lead the transition to a healthy planet and a new digital world’. And Health Commissioner Stella Kyriakides acknowledges that “European citizens expect the peace of mind that comes with access to health care… and protection against epidemics and diseases.”

The second session deals with the EU’s Beating Cancer Plan, and the conference will examine the new technologies, research and innovation that the Cancer Plan is taking as a starting point, in terms of setting out a new EU approach to cancer prevention, treatment and care.

Europe's Beating Cancer Plan will be supported by actions spanning across policy areas from employment, education, social policy and equality, through marketing, agriculture, energy, the environment and climate, to transport, cohesion policy, and taxation. A total of €4 billion is being earmarked for actions addressing cancer, including from the EU4Health programme, Horizon Europe and the Digital Europe programme. Expectations have been heightened by European strategists’ attachment to three key ingredients for courageous transformation: incentives, innovation, and investment. These reflect the pre-conditions for boosting health care into higher levels of efficiency, where the value of personalised medicine approaches can be fully appreciated and make its full contribution to Europe’s citizens.

This discussion of personalised health-care depicts a Europe where many chances for improvement are not yet fully being taken up. But this is not merely a catalogue of deficiencies. The variations and inefficiencies it presents are an argument for triggering radical rethinking, and for making the most of personalised health care. It highlights the endorsement of incentives, innovation, and investment by a new breed of Europe’s leaders. And it focuses on the ambitions that would support the development of personalised health care, diagnostics and medicines.

Everyone - from newborn babies to the elderly, from sufferers from chronic disease to acute cancer patients, and from health ministries to funding agencies - stands to gain. The price is nothing more than a shift in policy. The prize – in terms of value to the economy and to lives - is priceless.

As far as the role of biomarkers and advanced molecular diagnostics is concerned, the conference will also deal with this important subject in a latter session - today, biomarkers have immense scientific and potential clinical value in the diagnostic testing pipeline. They span the broad diagnostic sector from the genome to the phenome over various ‘-ome’ levels and have been used since the earliest days of the application of molecular biology. A biomarker signature is capable of revealing specific biological traits or measurable physiological changes, according to a disease status, physiological or pathological condition, or after drug application.

An understanding of biomarkers ties in to the existing new understanding of epidemiology, precision medicine, and pharmacogenomics, the deployment of technologies such as genomics, single cell sequencing, microbiome analysis and transcriptomics, and the opportunities arising from bioinformatics and digital innovations, which can be transformative for individual patients.

As novel gene-based diagnostics proliferate, they will be increasingly important to drug development, approval and later in clinical practice. There are numerous promising singular biomarkers or more complex multiple biomarker signatures available, the most important of which are currently used for assessing drug development, patient stratification or measuring the efficacy of treatment in therapeutic medicine. Clearly there is a translation problem to transfer the results from molecular diagnostics research to drug development and finally clinical practice. In future, biomarkers and their interaction on various levels will increase the molecular and cellular knowledge of disease and drug mechanisms.

To register for the conference, click here and click here for the agenda.

Von der Leyen proposes EU-wide health passport

The European Commission will present legislation for a digital health pass before the end of March. The announcement follows a virtual meeting between EU leaders last week, where Greece and Austria urged other states to adopt vaccination passports in order to restart travel and tourism. However, others remain on the fence due to concerns over vaccine efficacy and discrimination. Following the discussion of vaccines and travel restrictions by EU leaders during the European Council video conference, the bloc is taking further steps to reintroduce travel across the continent. European Commission President Ursula von der Leyen said in a tweet that legislation is being prepared for a ‘Digital Green Pass’. This will serve to provide proof of vaccination, test-results for “those who couldn’t get vaccine yet”, or information on COVID-19 recovery.

Von der Leyen, who has been the Commission’s president since December 2019, said that the digital pass was needed to facilitate Europeans’ lives. The proposal, she said, will be finalized and presented before the end of March.

That is everything for this week from EAPM – remember, registration is still open for the EU Presidency conference but only until the end of today (5 March) – 150 people have already signed up, click here to register and join them, and click here for the agenda. To those who will attend, EAPM looks forward very much to joining them on 8 March – stay safe and well, and have an excellent weekend.

Climate change

Big business seeks unified, market-based approaches ahead of climate summit

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Corporate executives and investors say they want world leaders at next week’s climate summit to embrace a unified and market-based approach to slashing their carbon emissions, write Ross Kerber and Simon Jessop.

The request reflects the business world’s growing acceptance that the world needs to sharply reduce global greenhouse gas emissions, as well as its fear that doing so too quickly could lead governments to set heavy-handed or fragmented rules that choke international trade and hurt profits.

The United States is hoping to reclaim its leadership in combating climate change when it hosts the 22-23 April Leaders Summit on Climate.

Key to that effort will be pledging to cut US emissions by at least half by 2030, as well as securing agreements from allies to do the same.

“Climate change is a global problem, and what companies are looking to avoid is a fragmented approach where the US, China and the EU each does its own thing, and you wind up with a myriad of different methodologies,” said Tim Adams, chief executive of the Institute of International Finance, a Washington-based trade association.

He said he hopes U.S. President Joe Biden and the 40 other world leaders invited to the virtual summit will move toward adopting common, private-sector solutions to reaching their climate goals, such as setting up new carbon markets, or funding technologies like carbon-capture systems.

Private investors have increasingly been supportive of ambitious climate action, pouring record amounts of cash into funds that pick investments using environmental and social criteria.

That in turn has helped shift the rhetoric of industries that once minimized the risks of climate change.

The American Petroleum Institute, which represents oil companies, for example, said last month it supported steps to reduce emissions such as putting a price on carbon and accelerating the development of carbon capture and other technologies.

API Senior Vice President Frank Macchiarola said that in developing a new U.S. carbon cutting target, the United States should balance environmental goals with maintaining U.S. competitiveness.

“Over the long-term, the world is going to demand more energy, not less, and any target should reflect that reality and account for the significant technological advancements that will be required to accelerate the pace of emissions reductions,” Macchiarola said.

Labor groups like the AFL-CIO, the largest federation of U.S. labor unions, meanwhile, back steps to protect U.S. jobs like taxing goods made in countries that have less onerous emissions regulations.

AFL-CIO spokesman Tim Schlittner said the group hopes the summit will produce “a clear signal that carbon border adjustments are on the table to protect energy-intensive sectors”.

Industry wish lists

Automakers, whose vehicles make up a big chunk of global emissions, are under pressure to phase out petroleum-fueled internal combustion engines. Industry leaders General Motors Co and Volkswagen have already declared ambitious plans to move toward selling only electric vehicles.

But to ease the transition to electric vehicles, US and European automakers say they want subsidies to expand charging infrastructure and encourage sales.

The National Mining Association, the US industry trade group for miners, said it supports carbon capture technology to reduce the industry’s climate footprint. It also wants leaders to understand that lithium, copper and other metals are needed to manufacture electric vehicles.

“We hope that the summit brings new attention to the mineral supply chains that underpin the deployment of advanced energy technologies, such as electric vehicles,” said Ashley Burke, the NMA’s spokeswoman.

The agriculture industry, meanwhile, is looking for market-based programs to help it cut its emissions, which stack up to around 25% of the global total.

Industry giants such as Bayer AG and Cargill Inc have launched programs encouraging farming techniques that keep carbon in the soil.

Biden’s Department of Agriculture is looking to expand such programs, and has suggested creating a “carbon bank” that could pay farmers for carbon capture on their farms.

For their part, money managers and banks want policymakers to help standardize accounting rules for how companies report environmental and other sustainability-related risks, something that could help them avoid laggards on climate change.

“Our industry has an important role to play in supporting companies’ transition to a more sustainable future, but to do so it is vital we have clear and consistent data on the climate-related risks faced by companies,” said Chris Cummings, CEO of the Investment Association in London.

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Brexit

UK asks for more time to respond to EU Brexit legal action: RTE TV

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Britain has asked for more time to respond to legal action taken by the European Union over its unilateral decision to ease requirements of the Northern Ireland Protocol, Ireland’s RTE television reported on Wednesday (14 April), writes Conor Humphries.

“The request came in two letters from the UK’s chief Brexit minister David Frost,” RTE correspondent Tony Connelly said in a Twitter post.

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EU

Team Europe increased Official Development Assistance to €66.8 billion as the world's leading donor in 2020

EU Reporter Correspondent

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The EU and its 27 member states have significantly increased their Official Development Assistance (ODA) for partner countries to €66.8 billion in 2020. This is a 15% increase in nominal terms and equivalent to 0.50% of collective Gross National Income (GNI), up from 0.41% in 2019, according to preliminary figures published today by the Organization for Economic Co-operation and Development's Development Assistance Committee (OECD-DAC). The EU and its member states thereby confirm their position as the world's leading donor, providing 46% of global assistance from the EU and other DAC donors, and have taken a major leap forward towards meeting the commitment to provide at least 0.7% of collective GNI as ODA by 2030.

International Partnerships Commissioner Jutta Urpilainen said: “Team Europe has significantly increased its contribution of Official Development Assistance compared to last year. This is crucial at a time when so many people in our partner countries face significant health, economic and social challenges linked to the COVID-19 crisis. The latest figures show that 10 years ahead of the due date to deliver on our commitment to provide 0.7% of our collective GNI as ODA, we are more determined than ever to achieve this target.”

Overall, 17 Member States increased their ODA in nominal terms in 2020 compared to 2019, with the strongest nominal increases coming from Germany (+€3.310bn), France (+€1.499bn) and Sweden (+€921 million), and further increases coming from Austria, Belgium, Bulgaria, Croatia, Cyprus, Denmark, Finland, Hungary, Latvia, Malta, Poland, Romania, Slovakia and Slovenia. The EU institutions' ODA (meaning the European Commission and the EIB) increased by €3.7bn (27%) overall in 2020 in nominal terms. 15 member states improved their ODA relative to their GNI by at least 0.01 percentage points: Austria, Belgium, Bulgaria, Croatia, Denmark, Finland, France, Germany, Hungary, Latvia, Malta, Romania, Slovakia, Spain and Sweden. In Cyprus and Greece, ODA as a share of GNI decreased by at least 0.01 percentage points.

In response to the coronavirus pandemic, the EU, its member states, and the European financial institutions, together with the European Investment Bank and the European Bank for Reconstruction and Development, have combined their financial resources as Team Europe, mobilising over €40bn in support to partner countries in 2020. 65% of this amount was already disbursed in 2020 in support of the immediate humanitarian needs; health, water, sanitation and nutrition systems, as well as tackling the social and economic consequences of the pandemic. The unprecedented nature of the COVID-19 crisis has put a huge stress on public finances and debt sustainability of many developing countries, affecting their ability to achieve the Sustainable Development Goals. This is why, in May 2020, President von der Leyen called for a Global Recovery Initiative, linking debt relief and investment to the SDGs to promote a green, digital, just and resilient recovery. The Global Recovery Initiative is about shifting to policy choices supporting green and digital transitions, social inclusiveness and human development while enhancing debt sustainability in partner countries.

ODA is one of the sources of financing to deliver on the SDGs, although more transparency is needed on all sources of finance for sustainable development. As an important step in that direction, data on Total Official Support for Sustainable Development (TOSSD) has been collected and published for the first time, increasing transparency on all officially-supported resources for the SDGs, including South-South co-operation, support to global public goods such as vaccine research and climate mitigation as well as private finance mobilized by official interventions.

Background

The data published today is based on preliminary information reported by the EU Member States to the OECD pending detailed final data to be published by OECD by early 2022. EU collective ODA consists of the total ODA spending of EU member states and the ODA of the EU institutions not attributed to individual member states or the UK (notably own resources of the European Investment Bank and, for the first time in 2020, special macro-financial assistance loans on a grant equivalent basis).

Despite its withdrawal from the European Union taking effect on 1 February 2020, the United Kingdom still contributed funding in the form of ODA to the EU budget and the European Development Fund in 2020. This is included in the EU institutions' ODA. However, in order to avoid double-counting between the ODA reported as EU collective ODA and the ODA reported by the United Kingdom itself, the United Kingdom's contribution to EU institutions is not included in what is reported as EU collective ODA.

Four EU member states already exceeded the 0.7% target of ODA as a share of GNI in 2020: Sweden (1.14%), Luxembourg (1.02%), Denmark (0.73%) and Germany (0.73%).

When highlighting the member states which increased or decreased their ODA as a share of GNI, only cases where the change amounts to at least 0.01 percentage points (based on exact rather than rounded values) are taken into account, while member states for which the change is smaller than 0.01 percentage points in either direction are considered to have kept their ODA as a share of GNI stable.

The EU and its member states thereby perform significantly above the average of non-EU DAC donors in terms of their ODA as a share of GNI, standing at 0.50% compared to 0.26% by the aggregate of all non-EU DAC donors.

In May 2015, the European Council reaffirmed its commitment to increase collective ODA to 0.7% of EU collective GNI by 2030. Since 2015, on a flow basis, ODA by the EU and its current 27 member states has grown by 37% (€18.7bn) in nominal terms while the ODA/GNI ratio has increased by 0.1 percentage points. The year 2020 marks a turn in the previous trend of declining ODA since the 2016 climax when the EU and its then 28 member states' ODA reached 0.52% of GNI. This turn is due partly to an absolute increase in collective ODA in nominal terms, and partly to an absolute decrease in collective GNI in nominal terms. The EU is also committed to give collectively between 0.15% and 0.20% of the EU GNI in the short term to Least Developed Countries (LDCs) and 0.20% by 2030. Since 2015, on a flow basis, ODA by the EU and its current 27 member states to LDCs has grown by 34% (€3.5bn) in nominal terms to reach €13.8bn (0.10% of GNI) in 2019, and the ODA to LDCs/GNI ratio has increased by 0.01 percentage points. Moreover, compared to 2018, the EU and its then 28 member states increased their aggregate ODA to Africa by 3.6% in nominal terms to €25.9bn in 2019. Data on ODA to LDCs, Africa and other specific recipients for 2020 are expected by early 2022.

Scaling up sustainable finance and private sector engagement in partner countries is essential, coupled with reforms to enhance business climates, as meeting the challenges of the Global Recovery Initiative cannot be achieved by ODA alone. The EU has been instrumental in bringing together aid, investment, trade, domestic resource mobilisation and policies designed to unlock the full potential of all financial flows. The European Fund for Sustainable Development guarantee in particular has played a key role in unlocking additional finance for partner countries. Over the last year alone, the EU signed €1.55bn worth of financial guarantees with our partner financial institutions, leveraging over €17bn of investments – also helping to ensure that recovery from the pandemic is green, digital, just and resilient.

More information

Q&A on preliminary figures on 2020 Official Development Assistance for the EU and its member states 

Annex Preliminary Figures on 2020 Official Development Assistance, Tables and Graphs for the EU and its member states

Commission's publication of figures on the global COVID-19 response

OECD press release

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