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Is there really a second wave of COVID-19 in Russia?

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The fresh statistics on the growth of new COVID-19 cases in Russia is indeed not much encouraging but rather sad. For the first time since the outbreak of the pandemic the number of infected detected during the last 24 hours exceeded 14.000 cases, writes Alex Ivanov. Moscow correspondent.

According to the official data, over the past day, 14,231 new cases of coronavirus were detected in Russia, and more than 1.3 million cases were registered in the country, the Operational headquarters for combating the spread of coronavirus reported. The largest number of cases per day was registered in Moscow – 4573, St. Petersburg – 602, Moscow region – 429.

In total, 1,340,409 virus-positive patients were identified in 85 regions, and the number of recovered patients increased to 1,039,705, of which 7,920 people were cured in the last 24 hours. Also, 239 fatal cases were recorded during the day. Over the entire period in Russia, 23,205 people died from coronavirus. On the eve of October 13, the number of confirmed cases of coronavirus per day was 13,868. Thus, the number of new cases per day increased by 363.

The mayor of Moscow Sergei Sobyanin, who is known of speaking very reluctantly about new restrictive measures as well as the possibility of the second wave of the pandemic, now seems to have changed his logic of handling the problem. It was quite expected that he had declared a two week vacation at schools in the beginning of October. Also elderly people of the age of 65 and above were insistently asked return to lockdown and not to leave their homes without a dire need.

Police and National Guard patrols increased their activity regarding observation of the mask wearing regime in public transport and other places like parks, shops.

The last of the announced measures require that school children from 5th to 11th class will study in the online mode, not attending schools. While students up to the 5th grade will go to schools.

Many parents as well teachers are not happy with this new regulation. Judging from the polls results, more than 60% of parents and teachers do not trust in the effectiveness of the online education.

Moscow authorities also ordered private companies to send 30% of their staff to work at home and are eager to tighten control over this measure, saying that it is “forced and temporary”.

At the same time official figures show that around 52 millions of Covid-19 tests were conducted in Russia (more than 1/3 of Russia’s population). But due a significant rise of new cases, the capacity of medical institutions to receive patients has sharply decreased.

Nevertheless doctors are encouraged with reports of the new vaccine introduction, which already has been widely announced.

Epidemiologists in Russia are very cautious with predictions of reaching the pandemic plato, but say it may happen in one month.

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Merkel plans circuit-break lockdown as German virus cases surge

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Chancellor Angela Merkel pressed regional leaders on Wednesday (28 October) to agree to a partial lockdown in Germany which would see restaurants and bars closed but keep schools open, a draft document seen by Reuters said, write and

The drastic measures, to take effect from 4 November, are aimed at curbing the spread of the coronavirus in Europe’s biggest economy as the number of new cases hit a record high.

Under the planned new restrictions people would only be able to go out with members of their own and one other household. Fitness studios, discos and cinemas would close, as would theatres, opera houses and concert venues.

Restaurants would only be allowed to offer takeaways, the document said. Shops could remain open if they implement hygiene measures and limit customer numbers.

Merkel will hold a virtual conference with the country’s 16 state premiers later to try to agree the nationwide rules and ditch a confusing patchwork of regional measures.

Almost all regions of Germany face an exponential increase in infection rates, said the document to be discussed, and local health authorities can no longer trace all infections.

“The aim is to interrupt the dynamic of the infection fast so no far-reaching limits on personal contact and economic activity are needed over the Christmas period,” it said.

Germany was widely praised for keeping infection and death rates below those of many of its neighbours in the first phase of the crisis but is now in the midst of a second wave. Cases rose by 14,964 to 464,239 in the last 24 hours, the Robert Koch institute for infectious diseases said on Wednesday.

Deaths jumped by 85 to 10,183, fuelling fears about the health system after Merkel warned on Tuesday it could hit breaking point if infections continue to spiral.

“If we wait until intensive care is full, it is too late,” Health Minister Jens Spahn, who last week tested positive for the virus, told broadcaster SWR.

The government has long insisted it wants to avoid a second blanket lockdown after an initial one this year hit economic growth, with the economy shrinking by a record 9.7% in the second quarter.

While economists expect a rebound for the July-Sept period, they warn that a further lockdown could wipe out growth in the last quarter. Third quarter data is due on 30 October.

Under the plans, the government aims to provide aid to firms hit by closures, including the cultural event sectors.

Only necessary overnight stays would be allowed, according to the document. Brothels, swimming pools, beauty and tattoo studios would close but physiotherapists and hairdressers could stay open. The steps would run until the end of November but are subject to review.

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Italy approves trial of osteoporosis drug to treat COVID-19

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Italy’s main medicines regulator gave the go-ahead on Tuesday (27 October) for human clinical trials on raloxifene, a generic osteoporosis drug that researchers hope may also help reduce COVID-19 symptoms and make patients less infectious, writes .

The drug was identified as a potential COVID-19 treatment by researchers using supercomputers to screen more than 400,000 molecules for chemical characteristics that might inhibit the virus, focusing on those already approved for use in humans.

Andrea Beccari, from Excalate4Cov, a public-private consortium led by Italy’s Dompé Farmaceutici, said researchers hoped that raloxifene - a generic drug known as a selective oestrogen receptor modulator - would block replication of the virus in cells and thus slow down progress of the disease.

“It inhibits virus replication, thus preventing the worsening of patients with mild symptoms, and also decreases infectivity, limiting the viral load,” said Marco Allegretti, head of research at Dompé Farmaceutici.

There was some evidence early in the coronavirus pandemic that oestrogen present in pre-menopausal women might have a protective effect against the virus. Some scientists think raloxifene, which is prescribed to strengthen the bones of older women with lower levels of oestrogen, the female hormone, may provide the same kind of protection.

The trial will involve 450 hospital and home patients at Rome’s Spallanzani Hospital and Humanitas in Milan in the initial phase.

They will be given a seven-day treatment of raloxifene capsules in a randomised sample and 174 more people may be added in the final stage. Enrolment will last 12 weeks.

The Excalate4Cov platform is backed by the European Commission and coordinates supercomputing centres in Italy, Germany and Spain with pharmaceutical companies and research centres, including the University of Louvain, Fraunhofer Institut, Politecnico di Milano and Spallanzani Hospital.

It uses a chemical library of 500 billion molecules and can process 3 million molecules per second using four supercomputers of more than 122 Petaflops, a unit of computing speed equal to one thousand trillion floating-point operations a second.

Researchers harnessed the power of the supercomputers to create a three-dimensional structure of 12 coronavirus proteins and conduct simulations to see where the proteins may be attacked by a drug.

“It took a million hours of calculation,” Beccari said, adding that, as research continued, it may be possible to develop second-generation drugs superior to raloxifene.

($1 = €0.8443)

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France sees highest number of COVID-19 patients going into hospital since April

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French hospitals registered 1,307 new coronavirus patients on Monday in the highest one-day increase since 2 April, which saw 1,607 new patients, as the health system comes under increasing stress from a runaway infection rate, writes Geert De Clercq.

French health ministry data showed that France now has a total of 17,784 coronavirus patients in its hospitals, compared with a record 32,292 on 14 April, at the height of the March-May lockdown.

The ministry also reported 26,771 new confirmed coronavirus cases in past 24 hours, from 52,010 on Sunday (25 October). On Monday, the tally usually drops sharply because of reporting lags over the weekend.

The death toll went up by 257, taking the cumulative total since the start of the epidemic to 35,018. The number of people in intensive care units rose by 186 to 2,770.

Several regions in France have implemented emergency plans in hospitals, delaying non-essential operations to make space in ICU units for COVID-19 patients and cancelling staff holidays.

Sources told Reuters that authorities were looking at options for still tighter measures to fight COVID-19, including starting a 9 p.m. to 6 a.m curfew earlier, confining people to their homes at weekends except for essential trips, and closing non-essential shops.

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